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The precise cause of Alzheimer’s Disease is unknown, but it is characterized by the death of brain cells. In Alzheimer’s Disease, the brain’s usual DNA repair activity is impaired, leading to mitochondrial dysfunction, lower neuron production, and increased neuronal dysfunction and inflammation. NAD+ is a compound that the brain needs to regulate DNA repair and other key signaling pathways. As NAD+ levels decline, the brain cells lose a critical DNA repair function that appears to inflict neurodegenerative diseases such as Alzheimer’s Disease.
Neuroscientists of the Johns Hopkins University School of Medicine teamed up with researchers at the National Institute on Aging to identify core mechanisms that contribute to Alzheimer’s disease development.
Their findings that were published in the Proceedings of the National Academy of Science, show that boosting NAD+ beneficially alters some of the pathological processes that contribute to brain-cell death in Alzheimer’s disease.
Golden, Barry. (2018 May). Nicotinamide Riboside. Life Extension Magazine.