Types of Ozone Therapy: A Complete Comparison
- May 11, 2023
- Written by : Rebecca LaMarca, MSN, APN-BC, CNS
Types of Ozone Therapy: A Complete Comparison
Key Takeaways
- The most common types of ozone therapy are MAH, MiAH, 10-pass, EBOO, rectal insufflation, ear insufflation, and prolozone injections.
- MAH is the most common entry-level IV method; 10-pass and EBOO are the most intensive; insufflation methods work well for needle-averse patients or targeted concerns.
- EBOO can treat over 3 liters of blood in a single session and delivers up to three times more ozone than other methods.
- The “best” type of ozone therapy depends on the individual — treatment goals, conditions, and needle tolerance all shape the right choice.
- IV Elements offers multiple ozone modalities in-lounge (Hoboken, Parsippany, Asbury Park, Marlton) and via mobile service across NJ, NYC, Philadelphia, and Bucks County, PA.
Many different types of ozone therapy exist, and each one comes with its own unique benefits. At IV Elements, our board-certified nurses offer multiple ozone modalities so you can choose one that fits your specific needs and treatment goals, whether you live in NJ, NYC, or Philadelphia. Here’s what you should know about each type of ozone therapy and how to figure out which one will work best for you.
Important: Ozone therapy has not been approved by the FDA to treat any health condition. Always talk to your licensed healthcare provider before starting any new treatment.
What are the different types of ozone therapy?
Quick answer: The most common types of ozone therapy are major autohemotherapy (MAH), minor autohemotherapy (MiAH), 10-pass ozone therapy, EBOO therapy, rectal insufflation, ear insufflation, and prolozone injections. Each method delivers ozone differently — through IV, injection, or gas — and is chosen based on the patient’s treatment goals and needle tolerance.
The most common types of ozone therapy are major autohemotherapy (MAH), minor autohemotherapy (MiAH), 10-pass ozone therapy, EBOO therapy, rectal insufflation, ear insufflation, and prolozone injections.
Looking for a step-by-step walk-through of how each method is delivered? See our complete guide to how ozone therapy is administered. This blog focuses on helping you compare methods and choose the right one.
Major autohemotherapy (MAH)
MAH is a type of ozone therapy in which blood is drawn through an IV line, mixed with ozone and oxygen, and reinfused through the same IV line. In general, we use lower concentrations of ozone for first-time sessions and higher concentrations for repeat sessions. Most MAH sessions last between 30 and 60 minutes.
Many people seek out MAH because they want to see if it can help with general issues like fatigue or brain fog, especially after intense exercise, sickness, or other stressors. Some people are also interested in the treatment’s potential to help with chronic conditions such as fibromyalgia, chronic infections like Lyme disease, autoimmune disorders, circulatory conditions, respiratory conditions, and musculoskeletal disorders. But more research is needed to determine if ozone can actually help with these conditions.
Minor autohemotherapy (MiAH)
MiAH is a type of ozone therapy in which a small amount of blood is drawn, briefly mixed with ozone and oxygen, and then injected into a muscle. Sessions tend to last between 10 and 30 minutes.
Since the ozonated blood is injected right into a muscle, MiAH triggers a quick immune response. That’s why some integrative health practitioners say it can support the immune system and help people fight off chronic issues like viral infections, eczema, acne, psoriasis, asthma, and seasonal allergies, though more studies are needed.
MiAH can also be a good option for people who dislike IVs; because it uses such a small amount of blood, it involves a quick blood draw with a syringe instead of a full IV drip.
10-pass ozone therapy
10-pass ozone therapy is an intensive form of ozone therapy in which blood is drawn into a sealed glass bottle, exposed to ozone under hyperbaric pressure, and reinfused up to ten times in a single session. The repeated passes and closed-system pressurization make it a more intensive method than MAH. It usually takes between 60 and 90 minutes.
Because 10-pass ozone therapy ozonates more blood than other methods, integrative health practitioners often recommend it for chronic conditions and more advanced forms of issues that people get MAH for, such as fatigue, inflammation, and infections.
Not sure which ozone method is right for you? Our clinician-led team offers private consultations to review your health history, goals, and needle tolerance so you can choose the modality that fits your care plan.
Schedule Your Consultation →EBOO therapy
EBOO (extracorporeal blood oxygenation and ozonation) therapy is an advanced type of ozone therapy in which blood is drawn and circulated through a filtration device that exposes it to ozone and filters it before it’s returned to the bloodstream. EBOO generally involves an ozone concentration of 1.5 mcg/mL – 4.5 mcg/mL and can treat over 3 liters of blood. A session usually lasts between 60 and 90 minutes, and studies show it delivers up to three times more ozone than other methods.
EBOO can treat a very large amount of blood at once, so practitioners may recommend it for more intense conditions like circulatory conditions, chronic infections, and autoimmune disorders. More research is needed to determine if EBOO can actually help treat these issues. Researchers are also exploring whether EBOO can help filter out toxins from the body.
Rectal insufflation
Rectal insufflation is a type of ozone therapy in which ozone gas is administered into the rectum via a catheter and then absorbed through the intestinal lining. In most cases, it involves an ozone concentration of 10 mcg/mL – 40 mcg/mL, and sessions take between 10 and 30 minutes.
Since it quickly enters your bloodstream through your gut, rectal insufflation is often recommended for conditions that affect the whole body, like chronic fatigue, chronic inflammation, and chronic infections. Some integrative health practitioners also recommend it for localized gastrointestinal disorders like inflammatory bowel disease (IBD) and chronic hemorrhoids, but more research is needed to see if ozone can actually help manage these conditions.
Ear insufflation
Ear insufflation is a type of ozone therapy in which ozone gas is passed through a humidifier and administered into the ear canal through a small device placed over or near the ear. It often involves an ozone concentration of 15 mcg/mL – 30 mcg/mL, with sessions taking between 10 and 30 minutes.
This type is usually recommended in integrative care settings for ear, nose, and throat conditions like chronic sinusitis, allergic rhinitis, tinnitus, and ear fungi. It might also be used for vertigo, chronic migraines, or brain fog. However, the FDA has not approved ear insufflation to treat any of these conditions.
Prolozone injections
A prolozone injection is a form of ozone therapy in which an oxygen-ozone mixture is injected directly into an injured joint, tendon, or ligament to support healing. The injection usually involves an ozone concentration of 10 mcg/mL – 25 mcg/mL, depending on the size of the injury. It tends to take about 10 to 30 minutes. Integrative health practitioners use it for musculoskeletal conditions like osteoarthritis, rheumatoid arthritis, chronic back or neck pain, rotator cuff injuries, and tendonitis.
Which type is most effective?
While it’s normal to ask which ozone therapy is best, there’s actually not one right answer because it depends on your specific treatment needs. For example, more intensive types like 10-pass ozone therapy and EBOO might work better for more serious conditions, prolozone injections may work best specifically for musculoskeletal injuries, and rectal or ear insufflation can work well for those who hate needles or have hard-to-find veins.
The board-certified nurses at IV Elements in NJ, NYC, and PA can help you consider all of the different ozone treatments and figure out which one would best meet your needs.
Multiple Ozone Modalities Available
Medically supervised ozone therapy — in-lounge across NJ or mobile across NJ, NYC, Philadelphia & Bucks County, PA.
Book Your ConsultationBegin medically supervised ozone therapy with IV Elements
To learn more about how ozone therapy methods compare, reach out to the clinician-led team at IV Elements. As members of the Physicians’ Association for Anthroposophic Medicine (PAAM), the Institute for Functional Medicine (IFM), and the Society for Integrative Oncology (SIO), we’re dedicated to helping you find the perfect type of ozone therapy for you. Led by Rebecca LaMarca (MSN, APN-BC), we offer customized in-lounge care in Hoboken, Parsippany, Asbury Park, and Marlton, along with convenient mobile treatments across NJ, NYC, Philadelphia, or Bucks County, PA. Schedule your consultation today!
Frequently Asked Questions
What’s the difference between MAH and 10-pass?
Both MAH and 10-pass ozone therapy involve drawing blood, exposing it to ozone, and reinfusing it. But while MAH only does this once, 10-pass ozone therapy repeats the process up to 10 times in a single session, meaning it exposes your body to a greater concentration of ozone.
What is EBOO, and how does it differ from regular ozone?
In EBOO (extracorporeal blood oxygenation and ozonation) therapy, blood is drawn and circulated through a filtration device that exposes it to ozone before it’s returned to the bloodstream. While regular ozone therapy (MAH) treats the blood in stages by drawing it, mixing it with ozone, and reinfusing it, EBOO continuously exposes blood to ozone for between 60 and 90 minutes, and it may also help filter out toxins. It can treat over 3 liters of blood in one session, and it provides up to three times more ozone than other techniques.
What is rectal ozone insufflation?
Rectal ozone insufflation is a type of ozone therapy where ozone gas is administered into the rectum with a catheter, and the ozone is then absorbed through the intestinal lining. Some integrative health practitioners use it for general issues like fatigue and inflammation, and others use it for localized gastrointestinal disorders like IBD.
Is IV ozone better than ear insufflation?
It depends on your treatment needs. In general, IV ozone might work better for issues affecting your whole body, like fatigue, inflammation, or infections. But ear insufflation might work best for issues affecting your ears, sinuses, or head, such as tinnitus, sinusitis, or migraines.
Where can I get ozone therapy in NJ?
You can get medically supervised ozone therapy in NJ at IV Elements’ drip lounges in Hoboken, Parsippany, Asbury Park, and Marlton. We also offer some of our ozone treatments through our mobile service that covers NJ, NYC, Philadelphia, and Bucks County, PA.
References
- IV Elements. What is IV Ozone Therapy? | Your Complete Guide. ivelements.net
- IV Elements. (2023, April 20). Understanding Ozone | How Different Treatments Work. ivelements.net
- IV Elements. (2025, November 6). 10 Pass IV Ozone. ivelements.net
- IV Elements. (2024, November 20). Benefits of EBOO Ozone. ivelements.net
- IV Elements. (2023, February 6). Conditions Treated by Ozone Therapy. ivelements.net
- Sucuoğlu, H., & Soydaş, N. (2023). Efficacy of Ozone Therapy as an Add-On Treatment in Fibromyalgia: A Randomized Double-Blind Placebo-Controlled Study. Journal of Back and Musculoskeletal Rehabilitation, 36(2), 357–366. pubmed.ncbi.nlm.nih.gov
- Rowen, R. J. (2018). Ozone Therapy as a Primary and Sole Treatment for Acute Bacterial Infection: Case Report. Medical Gas Research, 8(3), 121. pmc.ncbi.nlm.nih.gov
- IV Elements. (2023, April 20). 10-Pass Ozone Therapy Benefits. ivelements.net
- IV Elements. (2024, June 18). What is the difference between High Dose and 10 Pass Ozone? ivelements.net
- IV Elements. (2024, June 18). Kill Mold, HSV, Lyme & More With 10 Pass Ozone Treatment. ivelements.net
- IV Elements. (2024, May 17). Decreases HSV Outbreaks with Powerful 10 Pass Ozone Therapy. ivelements.net
- Rowen, R. J., Grabovac, S., & Su, T. B. (2022). Ozone dialysis delivers three or more times the ozone than other forms of ozone blood treatment. Medical Gas Research, 13(2), 67. doi.org
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Ozone IV Therapy Treatments
Ozone is a type of oxygen. Instead of two oxygen atoms connected to one another, ozone consists of three atoms. According to decades of research, this third atom brings a lot to the table.
